Author(s): Kang SK, Shin IS, Ko MS, Jo JY, Ra JC, Kang SK, Shin IS, Ko MS, Jo JY, Ra JC
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Abstract Human mesenchymal stem cells (MSCs) communicate with other cells in the human body and appear to "home" to areas of injury in response to signals of cellular damage, known as homing signals. This review of the state of current research on homing of MSCs suggests that favorable cellular conditions and the in vivo environment facilitate and are required for the migration of MSCs to the site of insult or injury in vivo. We review the current understanding of MSC migration and discuss strategies for enhancing both the environmental and cellular conditions that give rise to effective homing of MSCs. This may allow MSCs to quickly find and migrate to injured tissues, where they may best exert clinical benefits resulting from improved homing and the presence of increased numbers of MSCs.
This article was published in Stem Cells Int
and referenced in Journal of Pigmentary Disorders