alexa Kappa III immunoglobulin light chain origin of localized orbital amyloidosis.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Proteomics & Bioinformatics

Author(s): Hamidi Asl K, Liepnieks JJ, Nunery WR, Yazaki M, Benson MD

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Abstract Isolated orbital amyloidosis is a rare condition in which intra-muscular deposits result in proptosis and restriction of eye movement. Previous reports have suggested an immunoglobulin origin of the amyloid fibrils, but this has not been proven biochemically. A case is presented in which initial unilateral orbital amyloidosis progressed to bilateral disease. Biochemical analysis of resected ocular muscle determined that the amyloid fibrils were derived from a kappa III immunoglobulin light chain. Questions of pathogenesis and tissue tropism are considered.
This article was published in Amyloid and referenced in Journal of Proteomics & Bioinformatics

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