alexa Kappa opioids in rhesus monkeys. I. Diuresis, sedation, analgesia and discriminative stimulus effects.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Dykstra LA, Gmerek DE, Winger G, Woods JH

Abstract Share this page

Abstract The effects of the kappa agonists bremazocine, ethylketazocine, tifluadom and U-50,488 were examined in rhesus monkeys with four experimental procedures: urinary output was measured in normally hydrated monkeys; muscle relaxation and stupor were observed; and the time it took monkeys to withdraw their tails from warm water was evaluated. Lastly, the kappa agonists were examined in monkeys trained to respond differentially in the presence or absence of ethylketazocine. For comparison, morphine and another kappa agonist, Mr 2033, were examined under some of the procedures. Kappa agonists produced dose-dependent increases in urine output whereas morphine did not. Morphine, as well as each of the kappa agonists examined, produced dose-dependent increases in tail-withdrawal latencies from both 50 and 55 degrees C water; analgesic doses of kappa agonists produced marked stupor and muscle relaxation. Kappa agonists produced ethylketazocine-appropriate responding in the drug discrimination procedure. Doses of kappa agonists that produced ethylketazocine-appropriate responding were similar to doses that increased urine output and smaller than doses that increased tail-withdrawal latencies. The opioid antagonist quadazocine (WIN 44,441) antagonized the effects of bremazocine, ethylketazocine, tifluadom and U-50,488.
This article was published in J Pharmacol Exp Ther and referenced in Journal of Addiction Research & Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords