alexa kappa-Opioid activity of the four stereoisomers of the peripherally selective kappa-agonists, EMD 60,400 and EMD 61,753.


Journal of Addiction Research & Therapy

Author(s): Gottschlich R, Krug M, Barber A, Devant RM

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Abstract The four stereoisomers of the two peripherally selective kappa-opioid agonists EMD 60,400 and EMD 61,753 were synthesized, tested for stereoisomeric purity, and examined for affinity to the kappa opioid receptor. The relationships between the configuration of these molecules and their biological activity are discussed. This article was published in Chirality and referenced in Journal of Addiction Research & Therapy

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