alexa Keratomycosis: clinical and microbiologic experience with dematiaceous fungi
Ophthalmology

Ophthalmology

Journal of Clinical & Experimental Ophthalmology

Author(s): Garg P, Gopinathan U, Choudhary K, Rao GN

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Objective To assess the significance of dematiaceous fungi in the causation of keratomycosis. Design Retrospective, noncomparative case series. Participants Eighty-eight cases of dematiaceous fungal keratitis seen at the L. V. Prasad Eye Institute, Hyderabad, India from January 1991 through December 1996. Intervention Only culture-proven cases were analyzed. Main outcome measures Predisposing factors, clinical characteristics, microbiology, treatment methods, and outcome. Results Of 557 cases of fungal keratitis seen during the study period, dematiaceous fungi were the etiologic agents in 88 (15.7%), after Fusarium in 210 (37.6%) and Aspergillus species in 170 cases (30.4%), respectively. Trauma was the most common predisposing factor (47.7%). Fifty-three eyes (61.3%) had the classical clinical picture of yellow-white, dry raised infiltrate with feathery hyphate edges at initial examination. The characteristic macroscopic pigmentation was seen in only 24 eyes (27.27%). Septate branching fungal filaments were identified in 78 smears (88.63%) on light microscopy, of which 5 (5.7%) also showed the presence of bacteria. Curvularia species dominated the spectrum (22.7%). Treatment was started in 48 eyes with topical antifungal agents, whereas 37 received both oral and topical antifungal agents. Outcome data were available for 68 cases. Forty-nine (72%) responded to medical therapy, whereas 13 eyes required therapeutic penetrating keratoplasty and 6 eyes had to be eviscerated. Conclusions This is the largest series of keratitis caused by dematiaceous fungi reported to date. It clearly brings out the clinical importance of this group of corneal infections.

This article was published in Ophthalmology and referenced in Journal of Clinical & Experimental Ophthalmology

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