alexa Kinetic alterations of cytochrome-c oxidase in cystic fibrosis.
Genetics & Molecular Biology

Genetics & Molecular Biology

Hereditary Genetics: Current Research

Author(s): Battino M, Rugolo M, Romeo G, Lenaz G

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Abstract We compared the kinetics of cytochrome-c oxidase (cytochrome-c:oxygen oxidoreductase, EC 1.9.3.1) in fibroblasts derived from normal and cystic fibrosis individuals. The Km of the enzyme for reduced cytochrome c was significantly increased in CF cells; the change, however, was observed only at temperatures above 25 degrees C. The Vmax values were comparable in both types of individuals.
This article was published in FEBS Lett and referenced in Hereditary Genetics: Current Research

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