alexa Kinetics of tissue alpha-tocopherol uptake and depletion following administration of high levels of vitamin E.


Clinical & Medical Biochemistry

Author(s): Machlin LJ, Gabriel E, Machlin LJ, Gabriel E

Abstract Share this page

Abstract Following administration of high levels of vitamin E, plasma tocopherol levels in mature humans and monkeys continued to increase with time. In man plasma tocopherol levels were higher when tocopherol rather than tocopheryl acetate was given. Mature female rats that had been maintained on laboratory chow were put on the diet supplemented with either 1,000 or 10,000 mg/kg of all-rac-alpha-tocopheryl acetate. All tissues analyzed (plasma, platelets, liver, red blood cells, adipose tissue, heart, lung, skeletal muscle, and brain) continued to increase in tocopherol content for the duration of the supplement (20 weeks). It was concluded that it is difficult to saturate tissue with tocopherol and that not only the level, but the duration, of supplementation with vitamin E influences the concentration of vitamin E in all tissues. Liver and adipose tissue both accumulated tocopherol at a very rapid rate compared to other tissues, but once the chow diet was resumed, liver tocopherol decreased very rapidly and adipose tissue decreased very slowly. The studies suggest that at least for a short time period, the liver is the major available storage organ for tocopherol. When animals were put back on the unsupplemented chow diet, platelet and plasma levels returned to baseline values within 1 week, and red blood cells, heart, muscle, lung, and brain within 4 weeks.
This article was published in Ann N Y Acad Sci and referenced in Clinical & Medical Biochemistry

Relevant Expert PPTs

Relevant Speaker PPTs

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

1-702-714-7001Extn: 9042

General Science

Andrea Jason

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001Extn: 9042

© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version