alexa KIOM-79 inhibits aldose reductase activity and cataractogenesis in Zucker diabetic fatty rats.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Clinical & Experimental Pharmacology

Author(s): Kim J, Kim CS, Sohn E, Lee YM, Kim JS, Kim J, Kim CS, Sohn E, Lee YM, Kim JS

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Abstract OBJECTIVES: KIOM-79, a combination of four plant extracts, has a preventive effect on diabetic nephropathy and retinopathy in diabetic animal models. In this study, we have investigated the inhibitory effects of KIOM-79 on diabetic cataractogenesis. METHODS: We evaluated aldose reductase activity during cataractogenesis using Zucker diabetic fatty (ZDF) rat, an animal model of type 2 diabetes. ZDF rats were treated orally with KIOM-79 (50 mg/kg body weight) once a day for 13 weeks. KEY FINDINGS: In vehicle-treated ZDF rats, lens opacity was increased, and lens fibre swelling and membrane rupture were observed. In addition, aldose reductase activity and aldose reductase protein expression in diabetic lens were markedly enhanced. However, the administration of KIOM-79 inhibited the development of diabetic cataract through the inhibition of aldose reductase activity and protein expression in diabetic lenses. CONCLUSIONS: These observations suggested that KIOM-79 was useful against the treatment of diabetic cataractogenesis. © 2011 The Authors. JPP © 2011 Royal Pharmaceutical Society. This article was published in J Pharm Pharmacol and referenced in Journal of Clinical & Experimental Pharmacology

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