alexa Klebsiella bacteraemia: community versus nosocomial infection.


HIV: Current Research

Author(s): Yinnon AM, Butnaru A, Raveh D, Jerassy Z, Rudensky B

Abstract Share this page

Abstract In the period 1988-1993, 241 patients had Klebsiella bacteraemia at our medical centre. The annual number of patients with positive blood cultures increased from 306 in 1988 to 622 in 1993, representing a 4.5-6\% positivity rate of drawn cultures. After E. coli, Klebsiella was the leading cause of Gram-negative bacteraemia. During this period, the absolute number of Klebsiella bacteraemia increased from 25 in 1988 to 84 in 1993; this represents a true increase in Klebsiellaa bacteraemia, from 6-7\% of positive cultures in the late 1980s to 12-13\% in more recent years. There were 210 cases with K. pneumoniae and 31 with K. oxytoca. A representative sample of 80 records was retrieved and subdivided into two groups: community-acquired Klebsiella bacteraemia (CAKB) vs. hospital-acquired Klebsiella bacteraemia (HAKB). Urinary tract infection was the underlying source of 58\% of CAKB vs 28\% of HAKB (p < 0.01); pneumonia occurred significantly more often in HAKB (25\%) than in CAKB (7\%) (p < 0.01). In HAKB, as compared to CAKB, serious manifestations of illness were more common, e.g. shock (65\% vs. 37\%, p < 0.046) and respiratory failure (45\% vs. 20\%, p < 0.046). Overall mortality was 32\%, 22\% of patients with CAKB died vs. 42\% of those with HAKB (p < 0.05). Multiple drug resistance was very common: only 57\% of all Klebsiella strains were susceptible to gentamicin, 66\% to ceftriaxone, 70\% to ciprofloxacin, and 83\% to amikacin. The susceptibility rates of Klebsiella spp isolated from patients with HAKB were significantly lower (p < 0.001). Sepsis due to multiple-drug-resistant Klebsiellaa has become frequent, carrying significant morbidity and mortality. Restriction of broad-spectrum antimicrobials in the hospital and the community as well as implementation of infection control measures are needed to contain this problem.
This article was published in QJM and referenced in HIV: Current Research

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version