alexa Lactate dehydrogenase predicts hypoxic ischaemic encephalopathy in newborn infants: a preliminary study.


Journal of Neonatal Biology

Author(s): Karlsson M, WibergItzel E, Chakkarapani E, Blennow M, Winbladh B,

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Abstract BACKGROUND: Enzyme leakage as a result of hypoxia-ischaemia induced cell damage in affected organs is seen together with hypoxic ischaemic encephalopathy (HIE) after perinatal asphyxia. AIM: To investigate whether plasma lactate dehydrogenase [LDH], alanine aminotransferase [ALT] and aspartate aminotransferase [AST] during the first 12 h after birth predict HIE and adverse neurodevelopment outcome in newborn term infants with intra-partum signs of foetal distress. METHODS: Enzymes were measured within 12 h post partum in newborn infants with differing degree of HIE (n = 41) and in infants with signs of foetal distress during birth (n = 205) without HIE (non-HIE group). All infants were randomized into two groups. One group (n = 123) was used for calculation of cut off limits for the enzymes studied and the other group (n = 123) was used for calculation of the predictive value of the enzymes for detection of HIE. RESULTS: Using ROC curves, a cut off level of 1049 U/L for [LDH] was the best predictor of HIE (sensitivity 100\% and specificity 97\%) but also for long term outcome after HIE. CONCLUSION: [LDH] is a good predictor of HIE during the first 12 h after birth. This result is of clinical interest offering a potential inexpensive and safe prognostic marker in newborn infants with perinatal asphyxia. This article was published in Acta Paediatr and referenced in Journal of Neonatal Biology

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