alexa Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, double-blind, placebo-controlled trial.
Food & Nutrition

Food & Nutrition

Journal of Probiotics & Health

Author(s): Szajewska H, Gyrczuk E, Horvath A

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Abstract OBJECTIVE: To determine whether administration of Lactobacillus reuteri (L reuteri) DSM 17938 is beneficial in breastfed infants with infantile colic. STUDY DESIGN: Eighty infants aged <5 months with infantile colic (defined as crying episodes lasting 3 or more hours per day and occurring at least 3 days per week within 7 days prior to enrollment), who were exclusively or predominantly (>50\%) breastfed were randomly assigned to receive L reuteri DSM 17938 (10(8) colony-forming units) (n = 40) or an identically appearing and tasting placebo (n = 40), both orally, in 5 drops, 1 time daily, for 21 days. The primary outcome measures were the treatment success, defined as the percentage of children achieving a reduction in the daily average crying time ≥ 50\%, and the duration of crying (minutes per day) at 7, 14, 21, and 28 days after randomization. RESULTS: The rate of responders to treatment was significantly higher in the probiotic group compared with the placebo group at day 7 (P = .026), at day 14 (relative risk (RR) 4.3, 95\% CI 2.3-8.7), at day 21 (RR 2.7, 95\% CI 1.85-4.1), and at day 28 (RR 2.5, 95\% CI 1.8-3.75). In addition, throughout the study period, the median crying time was significantly reduced in the probiotic group compared with the control group. CONCLUSION: Exclusively or predominantly breastfed infants with infantile colic benefit from the administration of L reuteri DSM 17938 compared with placebo. TRIAL REGISTRATION: ClinicalTrials.gov NCT01046617. Copyright © 2013 Mosby, Inc. All rights reserved. This article was published in J Pediatr and referenced in Journal of Probiotics & Health

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