alexa Larger brains in medication naive high-functioning subjects with pervasive developmental disorder.


Autism-Open Access

Author(s): Palmen SJ, Hulshoff Pol HE, Kemner C, Schnack HG, Janssen J,

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Abstract BACKGROUND: Are brain volumes of individuals with Pervasive Developmental Disorder (PDD) still enlarged in adolescence and adulthood, and if so, is this enlargement confined to the gray and/or the white matter and is it global or more prominent in specific brain regions. METHODS: Brain MRI scans were made of 21 adolescents with PDD and 21 closely matched controls. RESULTS: All brain volumes, except the white matter, were significantly larger in patients. After correction for brain volume, ventricular volumes remained significantly larger in patients. CONCLUSIONS: Patients showed a proportional, global increase in gray matter and cerebellum volume, and a disproportional increase in ventricular volumes. Thus, at least in high-functioning patients with PDD, brain enlargement may still be present in adult life.
This article was published in J Autism Dev Disord and referenced in Autism-Open Access

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