alexa Large-scale brain networks and psychopathology: a unifying triple network model.
Medicine

Medicine

Evidence based Medicine and Practice

Author(s): Menon V, Menon V

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Abstract The science of large-scale brain networks offers a powerful paradigm for investigating cognitive and affective dysfunction in psychiatric and neurological disorders. This review examines recent conceptual and methodological developments which are contributing to a paradigm shift in the study of psychopathology. I summarize methods for characterizing aberrant brain networks and demonstrate how network analysis provides novel insights into dysfunctional brain architecture. Deficits in access, engagement and disengagement of large-scale neurocognitive networks are shown to play a prominent role in several disorders including schizophrenia, depression, anxiety, dementia and autism. Synthesizing recent research, I propose a triple network model of aberrant saliency mapping and cognitive dysfunction in psychopathology, emphasizing the surprising parallels that are beginning to emerge across psychiatric and neurological disorders. Copyright © 2011 Elsevier Ltd. All rights reserved. This article was published in Trends Cogn Sci and referenced in Evidence based Medicine and Practice

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