Author(s): OrozcoGmez LP, HernndezSalazar L, MoguelAncheita S, RamrezMoreno MA, MoralesCruz MV
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Abstract BACKGROUND: The "Early Treatment for Retinopathy of Prematurity Cooperative" reported a failure rate of 55.2\% using laser in zone 1 for treatment of retinopathy of prematurity (ROP). We need to offer better alternatives for those patients. We undertook this study to evaluate the efficacy of combined laser-ranibizumab therapy for ROP with threshold-prethreshold and "plus disease" and to study development of the newborn. METHODS: This is a prospective, experimental, longitudinal and open study including newborns of either <32 weeks of gestation or with a birth weight <1500 g, with threshold-prethreshold retinopathy or "plus disease." The effect of treatment was analyzed and development of the newborn was determined. RESULTS: We studied 34 eyes of 17 patients. Age at birth was 29.9 ± 2.6 weeks. Birth weight was 1,120 ± 253 g. The statistics demonstrated an important relationship between severity of retinopathy and early birth age, along with a high probability of threshold-prethreshold disease at 29.4 weeks of age or 1204 g birth weight. The Bayley scale reported normal development in 23.5\% of cases, global retardation in 23.5\%, psychomotor retardation but normal mental behavior in 29.4\%, and mental retardation but normal psychomotor development in 23.5\%. We demonstrated regression of retinopathy in all cases. Persistence of vascular tortuosity was present in 17.6\% of cases without vascular dilatation, and vitreous membrane development was demonstrated in 11.7\% of patients. CONCLUSIONS: Laser-ranibizumab treatment has allowed a better control of retinopathy for threshold-prethreshold and "plus disease" in this group of patients.
This article was published in Cir Cir
and referenced in Journal of Steroids & Hormonal Science