alexa Late onset hepatitis and prolonged deterioration in hepatic function associated with nevirapine therapy.


Journal of Antivirals & Antiretrovirals

Author(s): Clarke S, Harrington P, Condon C, Kelleher D, Smith OP,

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Abstract The aetiology of hepatic dysfunction in patients with HIV infection is multifactorial. Re-activation of hepatitis C infection, drug toxicity, and opportunistic infections are all potential causes. Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor used as part of combination antiretroviral therapy for the treatment of HIV infection. It is associated with a significant incidence of hepatotoxicity, usually occurring in the initial month of therapy. We report the case of a 49-year-old man who developed NVP-induced prolonged hepatotoxicity 5 months after commencing antiretroviral therapy.
This article was published in Int J STD AIDS and referenced in Journal of Antivirals & Antiretrovirals

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