alexa Late-onset Leclercia adecarboxylata bacteraemia in a premature infant in the NICU.


Journal of Neuroinfectious Diseases

Author(s): Myers KA, Jeffery RM, Lodha A

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Abstract Late-onset sepsis is a unique entity in the neonatal intensive care unit (NICU), as organisms involved are, by definition, nosocomial. As such, a limited number of microbes are characteristically involved. Leclercia adecarboxylata is a gram-negative bacillus rarely cultured in a clinical context, with the few published cases primarily involving immunocompromised adults. We present an ex-26-week newborn girl who developed late-onset sepsis with Leclercia adecarboxylata bacteraemia in the NICU. The infection was successfully treated with gentamicin and cefotaxime. This is the fifth paediatric report of Leclercia adecarboxylata infection, and the first in a neonate. The case raises the possibility that prior courses of antibiotics may have predisposed this individual to a rare infection essentially limited to immunocompromised individuals. CONCLUSION: Leclercia adecarboxylata is a rare infection, particularly in immunocompetent individuals. In neonates, the clinical course can be good with timely initiation of appropriate antibiotics. © 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica. This article was published in Acta Paediatr and referenced in Journal of Neuroinfectious Diseases

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