Author(s): Zhao D, Xiong Y, Lei QY, Guan KL
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Abstract LDH-A has been considered as a potential therapeutic target, based on its vital function in sustaining high rate of glycolysis in cancer cells. Indeed, LDH-A inhibitors and siRNA inhibited tumor growth in mouse models. Considering the inhibitory effect of K5 acetylation LDH-A, drugs that stimulate LDH-A acetylation by targeting the LDH-A acetyl transferase or deacetylase should inhibit LDH-A, therefore may have therapeutic value for cancers with high LDH-A activity. Taken together, our recent study not only demonstrates a novel mechanism of LDH-A regulation, but also provides a potential early diagnosis maker and therapeutic target for pancreatic cancer.
This article was published in Oncotarget
and referenced in Journal of Cell Science & Therapy