alexa Lembehsterols A and B, novel sulfated sterols inhibiting thymidine phosphorylase, from the marine sponge Petrosia strongylata.
Medicine

Medicine

Journal of Traditional Medicine & Clinical Naturopathy

Author(s): Aoki S, Naka Y, Itoh T, Furukawa T, Rachmat R, , Aoki S, Naka Y, Itoh T, Furukawa T, Rachmat R,

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Abstract Lembehsterols A (1) and B (2), two novel sulfated sterols, were isolated from the marine sponge Petrosia strongylata. Both sterols showed inhibitory activity against thymidine phosphorylase, which is an enzyme related to angiogenesis in solid tumors. The structures of these sulfated sterols were established on the basis of chemical and physicochemical evidence.
This article was published in Chem Pharm Bull (Tokyo) and referenced in Journal of Traditional Medicine & Clinical Naturopathy

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