alexa Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori.
Immunology

Immunology

International Journal of Inflammation, Cancer and Integrative Therapy

Author(s): Salama NR, Hartung ML, Mller A

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Abstract The bacterial pathogen Helicobacter pylori has co-evolved with humans and colonizes approximately 50\% of the human population, but only causes overt gastric disease in a subset of infected hosts. In this Review, we discuss the pathogenesis of H. pylori and the mechanisms it uses to promote persistent colonization of the gastric mucosa, with a focus on recent insights into the role of the virulence factors vacuolating cytotoxin (VacA), cytotoxin-associated gene A (CagA) and CagL. We also describe the immunobiology of H. pylori infection and highlight how this bacterium manipulates the innate and adaptive immune systems of the host to promote its own persistence.
This article was published in Nat Rev Microbiol and referenced in International Journal of Inflammation, Cancer and Integrative Therapy

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