alexa Lifetime risk of undergoing surgery for pelvic organ prolapse.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Tissue Science & Engineering

Author(s): Smith FJ, Holman CD, Moorin RE, Tsokos N

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Abstract OBJECTIVE: To investigate the lifetime risk of first-time incident pelvic organ prolapse (POP) surgery with the intention of updating previous risk estimates that have been based on members of managed-care populations. METHODS: Age-specific incidence rates of first-time prolapse surgery between 1981 and 2005 were calculated based on 44,728-incident cases. We estimated the lifetime risk as the cumulative incidence to age 85 years based on a life-table method and using the most recent cross-sectional incidence rates for the period 2001-2005. Age-standardized rates by calendar year were also calculated to show the secular trend in prolapse surgery. RESULTS: The lifetime risk of surgery for POP in the general female population was 19\% based on the most recent cross-sectional rates, a figure higher than the 11-12\% reported from U.S. managed-care populations. CONCLUSION: There is a relatively high likelihood that a woman in Western Australia will undergo surgery for POP during her lifetime. If, as our results suggest, the burden of genital prolapse in general populations is higher than previously thought, there is justification for a stronger evidence base for prevention, early detection and intervention to reduce the personal and societal costs of these gynecological conditions. LEVEL OF EVIDENCE: II. This article was published in Obstet Gynecol and referenced in Journal of Tissue Science & Engineering

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