alexa Lipid-Bloated Subretinal Microglial Cells Are at the Origin of Drusen Appearance in CX3CR1-Deficient Mice


Journal of Clinical & Experimental Ophthalmology

Author(s): Raoul W, Feumi C, Keller N, Lavalette S, Houssier M

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Drusen, the white yellowish deposits that can be seen in funduscopy, are a hallmark of age-related macular degeneration. Histologically, drusen are believed to be dome-shaped or more confluent lipid accumulations between the retinal pigment epithelium and the choriocapillaries. Recent advances in mouse funduscopy have revealed the presence of drusen-like structures in chemokine knockout animals in the absence of sizeable dome-shaped material below the retinal pigment epithelium. We show that aged CX3CR1–/– mice present with drusen-like appearance in funduscopy that is associated with a progressive age-related microglial cell accumulation in the subretinal space. We demonstrate that the anatomical equivalent of the drusen-like appearance in these mice are lipid-bloated subretinal microglial cells rather than subretinal pigment epithelium deposits [Combadière C, et al

This article was published in Ophthalmic Research and referenced in Journal of Clinical & Experimental Ophthalmology

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