alexa Lipopolysaccharide induces apoptosis in a bovine endothelial cell line via a soluble CD14 dependent pathway.


Immunotherapy: Open Access

Author(s): Frey EA, Finlay BB, Frey EA, Finlay BB, Frey EA, Finlay BB, Frey EA, Finlay BB

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Abstract We investigated the mode of bovine endothelial cell death induced by lipopolysaccharide (LPS). Inter-nucleosomal DNA fragmentation was observed indicating apoptotic cell death. Apoptosis was confirmed by examining cell morphology using confocal laser scanning and transmission electron microscopy, which revealed characteristic nuclear condensation in LPS-treated endothelial cells. Apoptosis was blocked by a monoclonal antibody against CD14, suggesting that LPS triggers apoptosis via a soluble CD14 (sCD14) dependent mechanism. Copyright 1998 Academic Press Limited.
This article was published in Microb Pathog and referenced in Immunotherapy: Open Access

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