Author(s): Saxena SJ, Honigberg IL, Stewart JT, Keene GR, Vallner JJ
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Abstract Operating conditions are described for the qualitative and quantitative determination of dantrolene sodium by high-pressure liquid chromatography. A 10-mum porous silica column was employed, using carbon tetrachloride-dimethylformamide (90:10) as the mobile phase. The flow rate was 2.0 ml/min (1800 psig), and the peaks were detected at 375 nm. The analysis of a dosage form can be carried out within 30 min with an accuracy of 3.1\%. The results agree favorably with those obtained with a modified spectrophotofluorometric method.
This article was published in J Pharm Sci
and referenced in Journal of Chromatography & Separation Techniques