alexa Liver mitochondrial respiratory functions decline with age.


Journal of Clinical & Experimental Pathology

Author(s): Yen TC, Chen YS, King KL, Yeh SH, Wei YH

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Abstract Human liver mitochondrial respiration rates in Chinese populations of various ages were assayed with an oxygraph. In this study, State 3 and State 4 respiration rates, respiratory control ratio (RCR), and ADP/O ratio were measured for 35 Chinese subjects of 31 to 76 years old. We found a significant negative correlation between age and respiratory control and ADP/O ratios tested. Moreover, the respiratory control and ADP/O ratios decreased with the increase of age. These findings suggest that a substantial fall in mitochondrial oxidative capacity in ageing liver may be an important contributor to the ageing process.
This article was published in Biochem Biophys Res Commun and referenced in Journal of Clinical & Experimental Pathology

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