alexa Local and systemic antibody response to oral administration of glucosyltransferase antigen complex.
Psychiatry

Psychiatry

Clinical Depression

Author(s): Smith DJ, Taubman MA, Ebersole JL

Abstract Share this page

Abstract The salivary and serum immune responses to orally administered glucosyltransferase antigen complex from Streptococcus mutants strain 6715 were investigated in hamsters. All enzyme-linked immunosorbent assay was used to measure the antibody quantity and isotype, and a [14C]glucosyl-labeled sucrose incorporation assay was used to measure functional inhibition of the enzyme. A total of 21 to 27 daily doses of antigen administered in hamster oral cavities elicited salivary immunoglobulin C and immunoglobulin A antibody responses and functional inhibitory activity. The salivary response increased throughout the immunization procedure, and the amount of salivary antibody was dependent upon the dose of antigen given. The salivary response to a second oral administration of antigen for 4 days showed some features of anamnesis. The response after a second antigen administration was detected sooner than the primary response, and somewhat higher levels of antibody and inhibitory activity were observed. Serum antibody (immunoglobulin G and immunoglobulin M) and functional inhibitory responses were also elicited by oral administration of the soluble enzyme antigen. These responses were lower than responses induced by local injections of antigen in complete Freund adjuvant. The ability to evoke a salivary immune response to the glucosyltransferase antigen complex may increase the potential of using this antigen in an effective caries vaccine.
This article was published in Infect Immun and referenced in Clinical Depression

Relevant Expert PPTs

Relevant Speaker PPTs

  • Enrique M. Ostrea
    Alluvial and riparian soils as major sources of lead exposure in young children in the Philippines: The role of floods
    PPT Version | PDF Version
  • Manche Santoshi Kumari
    Prevalence of otological disorders in diabetic patients with hearing loss
    PPT Version | PDF Version
  • Ehab Kamal
    Apitherapy in immune mediated disorders
    PPT Version | PDF Version
  • Pilar Montesó Curto
    Diagnosed, Identified, Current and Complete Depression Among Patients Attending Primary Care in Southern Catalonia: Different Aspects of the Same Concept
    PPT Version | PDF Version
  • George Stoica
    Movement Disorder and Neurodegeneration in a Rat Model with Myosin 5a Mutation
    PPT Version | PDF Version
  • Yosef Yarden
    Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
    PPT Version | PDF Version
  • Sahreen Malik Bhanji
    Social determinants of depression among HIV positive patients in Karachi, Pakistan
    PPT Version | PDF Version
  • Abdalla Omar
    Study of Some Egyptian Plants of Potential Use in Some Cases of Hepatic Disorders
    PPT Version | PDF Version
  • Sergey Suchkov
    Translational tools as applicable to autoimmune disorders: antibody-proteases as a generation of highly informative and unique biomarkers to monitor subclinical and clinical stages of demyelination in multiple sclerosis (MS)
    PPT Version | PDF Version
  • Rathnasiri Bandara
    Migraine and neurological disorders comorbidity: Consideration of sinus hypoxic nitric oxide theory
    PPT Version | PDF Version
  • Hui-Mei Chen
    Randomised Controlled Trial on the Effectiveness of Home-Based Walking Exercise on Depression in Patients with Lung Cancer
    PPT Version | PDF Version
  • Heather MacDonald
    Removing the mask: Women returning to work after a lapse due to depression
    PPT Version | PDF Version
  • John J Power
    A study exploring disordered eating patterns in first-year university students: student and service needs
    PPT Version | PDF Version
  • Afaf El-Ansary
    Dysregulated redox balance associated with glutamate excitotoxicity in autism spectrum disorders
    PPT Version | PDF Version
  • Anahid Kulwicki
    Post Traumatic Stress Disorder (ptsd) in post-earthquake haitian adults with traumatic amputations
    PPT Version | PDF Version

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords