Author(s): Koistinaho J, Sagar SM
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Abstract The localization of PKC subspecies alpha, beta, gamma, epsilon and zeta was studied immunocytochemically in the rabbit retina. Conventional, Ca(2+)-sensitive PKC subtypes alpha, beta, gamma were all localized in different neuronal populations. The zeta-subspecies, which does not require Ca2+ for activation, was colocalized with PKC-alpha. PKC-epsilon, which is independent of Ca2+ and DAG, was colocalized with PKC-beta. Some populations of neurons, including cone bipolar cells, contained none of the PKC-subspecies studied. These results imply a cellular segregation of different signaling pathways in mammalian retina.
This article was published in Neurosci Lett
and referenced in Journal of Diabetes & Metabolism