alexa Loloatins A-D, cyclic decapeptide antibiotics produced in culture by a tropical marine bacterium.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Gerard JM, Haden P, Kelly MT, Andersen RJ

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Abstract Loloatins A (1) to D (4), a family of new cyclic decapeptide antibiotics, have been isolated from laboratory cultures of a tropical marine bacterium recovered from the Great Barrier Reef in Papua New Guinea. The structures of loloatins A-D were elucidated via a combination of spectroscopic analyses and chemical degradation. Loloatins A-D exhibit in vitro antimicrobial activity against methicillin-resistant Staphyloccoccus aureus, vancomycin-resistant enterococci, and drug-resistant Streptococcus pneumoniae. This article was published in J Nat Prod and referenced in Pharmaceutica Analytica Acta

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