alexa [Long term follow-up of 799 children with isolated ventricular septal defects].
Cardiology

Cardiology

Journal of Clinical & Experimental Cardiology

Author(s): Erdem S, Ozbarlas N, Kkosmanolu O, Poyrazolu H, Salih OK

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Abstract OBJECTIVES: We evaluated long-term follow-up results and prognosis of pediatric patients with isolated ventricular septal defects (VSD). STUDY DESIGN: The study included 799 patients (368 girls, 431 boys; mean age at diagnosis 24.3±37.4 months; median 6 months) who were monitored by the pediatric cardiology department for VSD. The mean follow-up period was 32.8±30.3 months (median 20 months). RESULTS: The VSDs were classified as perimembranous (n=610, 76.4\%), muscular (n=171, 21.4\%), doubly committed subarterial (n=10, 1.3\%), and multiple (n=8, 1\%). Spontaneous closure rates were 42.7\%, 13.1\%, and 25\% in muscular, perimembranous, and multiple VSDs, respectively, which corresponded to a mean age of 18.6±19.9 months (median 12 months) in muscular and 30.2±33.7 months (median 14.5 months) in perimembranous VSDs. Before 2 years of age, 78.1\% of muscular and 58.6\% of perimembranous VSDs underwent spontaneous closure. Of 256 defects (32\%) that required surgical closure, 91.4\% were of perimembranous location. The mean age at surgery was 38.8±49.1 months (median 11 months) for muscular, and 43.7±40.9 months (median 24 months) for perimembranous defects. During the follow-up period, the following complications were noted: aortic valve prolapse (0.7\%), aortic regurgitation (0.6\%), left ventricle-to-right atrium shunt (2.6\%), subaortic ridge (3.7\%), and infundibular stenosis (1.2\%). Aortic regurgitation developed in eight patients (3.7\%) after surgical closure. CONCLUSION: Our data on the natural course and prognosis of VSDs may be of relevance with respect to patients' age, defect type, and complications encountered in the follow-up period.
This article was published in Turk Kardiyol Dern Ars and referenced in Journal of Clinical & Experimental Cardiology

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