Author(s): Fransen S, Karmochkine M, Huang W, Weiss L, Petropoulos CJ, , Fransen S, Karmochkine M, Huang W, Weiss L, Petropoulos CJ,
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Abstract We characterized the raltegravir (RAL) susceptibility and the integrase (IN)-mediated replication capacity (RC) of RAL-resistant human immunodeficiency virus type 1 from two patients experiencing virologic failure during continuous RAL salvage therapy. The following two distinct outcomes were observed: (i) the selective outgrowth of virus with high-level RAL resistance and high IN-mediated RC leading to significant viral load rebound and (ii) the selection of virus with a slight reduction in RAL susceptibility and low IN-mediated RC resulting in sustained low-level viremia.
This article was published in Antimicrob Agents Chemother
and referenced in Journal of AIDS & Clinical Research