alexa Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10-year prospective study.
Immunology

Immunology

Journal of Allergy & Therapy

Author(s): Di Rienzo V, Marcucci F, Puccinelli P, Parmiani S, Frati F

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BACKGROUND: Subcutaneous immunotherapy for respiratory allergy has shown a long-lasting efficacy after its discontinuation, whereas this evidence is still lacking for sublingual immunotherapy, despite the fact that it is widely used. OBJECTIVE: We aimed to evaluate whether a long-lasting effect of SLIT occurs, in a prospective parallel group controlled study. METHODS: Sixty children (mean age 8.5 years) suffering from allergic asthma/rhinitis due to mites were subdivided into two matched groups: 35 underwent a 4- to 5-year course of SLIT with standardized extract and 25 received only drug therapy. The patients were evaluated at three time points (baseline, end of SLIT and 4 to 5 years after SLIT discontinuation) regarding presence of asthma, use of anti-asthma drugs, skin prick tests and specific IgE. RESULTS: We found that in the SLIT group there was a significant difference vs. baseline for the presence of asthma (P

This article was published in Clin Exp Allergy. and referenced in Journal of Allergy & Therapy

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