Author(s): Vien NC, Feroldi E, Lang J
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Abstract Vietnamese children received purified Vero cell rabies vaccine 1 year after a primary series (Y0) and again 5 years later (Y5), either as intramuscular or 1/5th dose intradermal injections concomitant with diphtheria, tetanus, pertussis and oral poliomyelitis vaccines. Antibody levels were assayed annually for 5 years. All subjects in both groups had anti-rabies antibody titres considered protective after the Y0 booster. Rabies seroprotection rates and geometric mean titres gradually decreased similarly in both groups. Seroprotection after the Y5 booster was 100\% in both groups. Satisfactory immunogenicity, long-term antibody persistence and an anamnestic response were conferred by both routes, greatly simplifying any future post-exposure prophylaxis.
This article was published in Trans R Soc Trop Med Hyg
and referenced in Journal of Microbial & Biochemical Technology