alexa Long-term evaluation of patients with hydatidosis treated with benzimidazole carbamates.


Journal of Gastrointestinal & Digestive System

Author(s): Franchi C, Di Vico B, Teggi A

Abstract Share this page

Abstract Four hundred forty-eight patients with 929 Echinococcus granulosus hydatid cysts received 3- to 6-month continuous cycles of mebendazole or albendazole treatment and underwent prolonged follow-up by clinical visits and imaging studies (range, 1-14 years) to assess the long-term outcome of treatment. Degenerative changes and relapse were assessed by imaging techniques. At the end of therapy, 74.1\% of the hydatid cysts showed degenerative changes. These were more frequent in albendazole-treated than in mebendazole-treated cysts (82.2\% vs. 56.1\%; P < .001). During long-term follow-up, 104 cysts (22\%) had degenerative changes that progressed, whereas 163 cysts (approximately 25\%) relapsed. The percentages of relapses in the two drug-treated groups were almost the same. Relapses occurred more frequently in type II cysts of the liver. Cysts recurred most often (78.5\%; P < .001) within the first 2 years after treatment ended. Further chemotherapy cycles induced degenerative changes in >90\% of relapsed cysts without inducing more frequent or more severe side effects than those observed during the initial cycles. This article was published in Clin Infect Dis and referenced in Journal of Gastrointestinal & Digestive System

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version