Author(s): Franchi C, Di Vico B, Teggi A
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Abstract Four hundred forty-eight patients with 929 Echinococcus granulosus hydatid cysts received 3- to 6-month continuous cycles of mebendazole or albendazole treatment and underwent prolonged follow-up by clinical visits and imaging studies (range, 1-14 years) to assess the long-term outcome of treatment. Degenerative changes and relapse were assessed by imaging techniques. At the end of therapy, 74.1\% of the hydatid cysts showed degenerative changes. These were more frequent in albendazole-treated than in mebendazole-treated cysts (82.2\% vs. 56.1\%; P < .001). During long-term follow-up, 104 cysts (22\%) had degenerative changes that progressed, whereas 163 cysts (approximately 25\%) relapsed. The percentages of relapses in the two drug-treated groups were almost the same. Relapses occurred more frequently in type II cysts of the liver. Cysts recurred most often (78.5\%; P < .001) within the first 2 years after treatment ended. Further chemotherapy cycles induced degenerative changes in >90\% of relapsed cysts without inducing more frequent or more severe side effects than those observed during the initial cycles.
This article was published in Clin Infect Dis
and referenced in Journal of Gastrointestinal & Digestive System