Author(s): Schuller E, Jilma B, Voicu V, Golor G, Kollaritsch H,
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Abstract Japanese encephalitis (JE) is the most common viral encephalitis in Asia. IC51 is a new Vero cell-derived, inactivated JE virus vaccine with non-inferior immunogenicity (after 2 months) compared to the US-licensed vaccine JE-VAX (mouse brain-derived, inactivated) and with a more convenient (two injections instead of three) intramuscular dose schedule. Adult subjects from two studies were followed-up for comparative immunogenicity (JE-VAX) at 6 months and long-term immunogenicity of IC51 alone at 12 months. At 6 months, immunogenicity was higher with IC51 (seroconversion rate [SCR] 95\%; geometric mean titer [GMT] 84) than with JE-VAX (SCR 74\%; GMT 34). At 12 months, the SCR was 83\% and the GMT (41) remained above the protective titer of 1:10. Most people immunized with IC51 will have protective neutralizing antibody levels for at least a year.
This article was published in Vaccine
and referenced in Journal of Bioterrorism & Biodefense