alexa Long-term outcomes of renal transplants from spousal and living-related and other living-unrelated donors: a single center experience.
Nephrology

Nephrology

Journal of Nephrology & Therapeutics

Author(s): Kute VB, Shah PR, Vanikar AV, Gumber MR, Goplani KR,

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Abstract BACKGROUND: Deceased donor organ shortage has made living donors (LD) major source for renal transplantation (RTx) in India. Spouses represent an important source of allograft. We carried out a retrospective study of spousal RTx vs. other LDRTx to compare long-term results. METHODS: This retrospective single-center study was undertaken to evaluate demographic, patient survival, graft survival, function vis-à-vis serum creatinine (SCr) and rejection episodes in 1523 living donor renal allograft recipients from 1998 to 2009. It included spouse donors (n=337) (group 1), living related donors (LRD) (n=969) (group 2), and living unrelated donors (LUD) (n=217) (group 3). RESULTS: Mean recipient age (years +/- SD)) was 41.48 +/- 8.87, 30.49 +/- 10.61, and 37.13 +/- 13.25, respectively for the three groups who were followed for 4.47 +/- 3.03, 4.47 +/- 3.0 and 5.15 +/- 3.28 years respectively. Female donors were 92.6\%, 66.4\%, and 41\%, mean HLA match was 1.15 +/- 0.93, 3 +/- 1.05 and 1.30 +/- 1.08 respectively. One, 5 and 12 year graft survivals among group 1 were 91.39\%, 75.49\%, and 73.13\%; 90.98\%, 74.10\% and 64.57\% in group 2 and 94.92\%, 82.86\% and 70.31\% in group 3. Patient survival for 1, 5 and 12 years were 89.31\%, 72.55\% and 66.58\% in group 1, 93.57\%, 82.25\% and 72.23\% in group 2, and 92.62\%, 79.76\% and 66.79\% in group 3. Acute rejections were noted in 16.6\%, 15.8\% and 17\% respectively. CONCLUSIONS: In circumstances of organ shortage andunavailability of well developed ABO incompatible transplants, spousal donation is viable option.
This article was published in J Assoc Physicians India and referenced in Journal of Nephrology & Therapeutics

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