alexa Long-term survival rates in young patients with thyroid carcinoma.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Thyroid Disorders & Therapy

Author(s): Kowalski LP, Gonalves Filho J, Pinto CA, Carvalho AL, de Camargo B

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Abstract BACKGROUND: Thyroid carcinoma in patients younger than 18 years is rare. It is associated with a greater risk of metastases. However, the prognosis for these patients is better when compared with that of adults. OBJECTIVE: To present the experience of a single institution in the treatment of patients with thyroid carcinoma during childhood and adolescence. PATIENTS AND METHODS: Thirty-eight patients, ranging in age from 4 to 18 years, were diagnosed as having thyroid carcinoma. Pathologic types of carcinoma included 29 papillary, 4 follicular, 1 Hürthle cell, and 4 medullary cases. RESULTS: Hypocalcemia was the main complication, being transitory in 9 patients (24\%) and permanent in 6 patients (16\%). Vocal cord palsy occurred in 2 patients (5\%). Two patients (5\%) had a surgical site infection. After a mean follow-up of 9.5 years (range, 1-40 years), 28 patients (74\%) were alive and had no evidence of disease, 3 (8\%) were alive and had recurrent disease, 4 (11\%) died (2 of the disease and 2 of non-cancer-related causes), and 3 (8\%) were lost to follow-up. The survival rates at 10 years for the patients with papillary, follicular, and medullary carcinoma were 93\%, 100\%, and 50\%, respectively. CONCLUSIONS: Thyroid carcinoma in patients younger than 18 years has a good prognosis even in the presence of neck or distant metastasis. Total thyroidectomy, associated with adjuvant radioactive iodine therapy and thyroidal suppression or not, is effective in patients with a well-differentiated thyroid carcinoma. This article was published in Arch Otolaryngol Head Neck Surg and referenced in Journal of Thyroid Disorders & Therapy

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