alexa Long-term therapeutic effect of novel calcium phosphate-based compounds injected in ovariectomized rats.


Bioceramics Development and Applications

Author(s): Tokudome Y, Otsuka M, Ito A, LeGeros RZ

Abstract Share this page

Abstract The specific aim of this study was to evaluate the efficacy of well-characterized Mg/Zn/F-CaP preparations (administered by injection) in preventing bone mineral deficiency in ovariectomized (OVX) rats. Donryu rats (4 weeks old, average weight 70 g) were divided into six experimental groups: GN (normal), GC (control, OVX), and OVX rats injected with suspensions of MZF-CaPs (G2, G3, and G4) or with Zn-containing tricalcium phosphate (ZnTCP, G1). The composition of the preparations was G1: 34.1 wt \% Ca; 19.5 wt \% P; and 6.17 wt \% Zn; G2 (#51): 23.7 wt \% Ca; 13.6 wt \% P; 1.1 wt \% Mg; 2.9 wt \% Zn, and 1.1 wt \% F; G3 (#68): 22.4 wt \% Ca; 14.1 wt \% P; 2.6 wt \% Mg, 2.6 wt \% Zn, and 2.3 wt \% F; G4 (#76): 28.5 wt \% Ca; 15.5 wt \% P; 1.9 wt \% Mg, 1.8 wt \% Zn, and 3.0 wt \% F. The suspensions (10 mg/0.2 mL) were injected into the right thigh once a week for 12 weeks. Bone mineral density (BMD) was measured by X-ray computed tomography and bone mechanical strength (BMS) was measured as femoral three-point bending strength. BMD and BMS were significantly higher in the femurs from groups G1, G2, G3, and G4 than from GC. No significant difference was observed in BMD or BMS between the left and right femurs for any group. The results indicate that the injected Mg/Zn/F-CaP compounds were effective in preventing bone loss induced by ovariectomy in rats and suggest that these compounds have potential use for treating osteoporosis. (c) 2009 Wiley Periodicals, Inc. This article was published in J Biomed Mater Res B Appl Biomater and referenced in Bioceramics Development and Applications

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version