alexa Loss of heterozygosity or: how I learned to stop worrying and love mitotic recombination


Journal of Carcinogenesis & Mutagenesis

Author(s): Tischfield JA

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Since Knudson's (1993) so-called two-hit hypothesis has been shown to explain the origin of many different cancers with a dominant pattern of inheritance, the term “loss of heterozygosity” (“LOH”) has acquired new and increased significance with regard to malignancy. In this article, however, I discuss the implications of recent findings regarding the frequency, nature, and consequences of LOH in normal somatic cells in vivo. I also will propose a broad operational definition of LOH, since the term has been used inconsistently in the literature, mostly in connection with cancers, and often interchangeably with terms such as “allelic imbalance” and “reduction to homozygosity.”

This article was published in Am J Hum Genet. and referenced in Journal of Carcinogenesis & Mutagenesis

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