alexa Low plasma cefepime levels in critically ill septic patients: pharmacokinetic modeling indicates improved troughs with revised dosing.


Journal of Clinical Toxicology

Author(s): Lipman J, Wallis SC, Rickard C

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Abstract The pharmacokinetics of a 2-g bolus of cefepime were measured in critically ill patients with normal renal function. Variable and low trough plasma drug concentrations were found, and 8 of 10 patients had levels below the MIC at which 50\% of the isolates are inhibited for Pseudomonas aeruginosa. Computer simulations predicted that continuous infusion and shorter dosing intervals would increase trough levels.
This article was published in Antimicrob Agents Chemother and referenced in Journal of Clinical Toxicology

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