alexa Low risk of liver toxicity using the most recently approved antiretroviral agents but still increased in HIV-hepatitis C virus coinfected patients.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Vispo E, FernndezMontero JV, Labarga P, Barreiro P, Soriano V, Vispo E, FernndezMontero JV, Labarga P, Barreiro P, Soriano V

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Abstract Liver enzyme elevations (LEE) were investigated in 2717 episodes of initiation of antiretroviral therapy since January 2010 in 1982 HIV patients. Serum hepatitis C virus (HCV)-RNA was positive in 24\%. Any grade of LEE was recognized in 9\% of episodes, being 6\% in HCV-negative and 17\% in HCV-positive patients (P < 0.001). Grades 3-4 LEE only occurred in 0.4\% of patients. Overall, LEE were more frequent with ritonavir-boosted darunavir and atazanavir than with raltegravir and etravirine. This article was published in AIDS and referenced in Journal of AIDS & Clinical Research

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