Author(s): Candow DG, Little JP, Chilibeck PD, Abeysekara S, Zello GA,
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Abstract PURPOSE: To determine whether low-dose creatine and protein supplementation during resistance training (RT; 3 d x wk(-1); 10 wk) in older men (59-77 yr) is effective for improving strength and muscle mass without producing potentially cytotoxic metabolites (formaldehyde). METHODS: Older men were randomized (double-blind) to receive 0.1 g x kg(-1) creatine + 0.3 g x kg(-1) protein (CP; n = 10), creatine (C; n = 13), or placebo (PLA; n = 12) on training days. Measurements before and after RT included lean tissue mass (air-displacement plethysmography), muscle thickness (ultrasound) of elbow, knee, and ankle flexors and extensors, leg and bench press strength, and urinary indicators of cytotoxicity (formaldehyde), myofibrillar protein degradation [3-methylhistidine (3-MH)],and bone resorption [cross-linked N-telopeptides of type I collagen (NTx)]. RESULTS: Subjects in C and CP groups combined experienced greater increases in body mass and total muscle thickness than PLA (P < 0.05). Subjects who received CP increased lean tissue mass (+5.6\%) more than C (+2.2\%) or PLA (+1.0\%; P < 0.05) and increased bench press strength (+25\%) to a greater extent than C and PLA combined (+12.5\%; P < 0.05). CP and C did not differ from PLA for changes in formaldehyde production (+24\% each). Subjects receiving creatine (C and CP) experienced a decrease in 3-MH by 40\% compared with an increase of 29\% for PLA (P < 0.05) and a reduction in NTx (-27\%) versus PLA (+13\%; P = 0.05). CONCLUSIONS: Low-dose creatine combined with protein supplementation increases lean tissue mass and results in a greater relative increase in bench press but not leg press strength. Low-dose creatine reduces muscle protein degradation and bone resorption without increasing formaldehyde production.
This article was published in Med Sci Sports Exerc
and referenced in Journal of Obesity & Weight Loss Therapy