alexa Lumbar total disc replacement from an extreme lateral approach: clinical experience with a minimum of 2 years' follow-up.
Neurology

Neurology

Journal of Spine

Author(s): Pimenta L, Oliveira L, Schaffa T, Coutinho E, Marchi L

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Abstract OBJECT: current lumbar total disc replacement (TDR) devices require an anterior approach for implantation. This approach has inherent limitations, including risks to abdominal structures and the need for resection of the anterior longitudinal ligament (ALL). Placement of a TDR device from a true lateral (extreme lateral interbody fusion [XLIF]) approach is thought to offer a less invasive option to access the disc space, preserving the stabilizing ligaments and avoiding scarring of anterior vasculature. In this study, the authors attempted to quantify the clinical and radiographic outcomes of a lateral approach to lumbar TDR from a prospective, single-center experience. METHODS: a TDR device designed for implantation through a true lateral, retroperitoneal, transpsoas approach (XLIF) was implanted in 36 patients with discography-confirmed 1- or 2-level degenerative disc disease. Clinical (pain and function) and radiographic (range of motion [ROM]) data were prospectively collected preoperatively, postoperatively, and serially for a minimum of 24 months' follow-up. RESULTS: thirty-six surgeries were performed in 16 men and 20 women (mean age 42.6 years). Surgeries included 15 single-level TDR procedures at L3-4 or L4-5, three 2-level TDR procedures spanning L3-4 and L4-5, and 18 hybrid procedures (anterior lumbar interbody fusion [ALIF]) at L5-S1 and TDR at L4-5 [17] or L3-4 [1]). Operative time averaged 130 minutes, with an average blood loss of 60 ml and no intraoperative complications. Postoperative radiographs showed good device placement. All patients were walking within 12 hours of surgery and all but 9 were discharged the next day (7 of 9 had hybrid TDR/ALIF procedures). Five patients (13.8\%) had psoas weakness and 3 (8.3\%) had anterior thigh numbness postoperatively, both resolving within 2 weeks. One patient (2.8\%) demonstrated weakness of the leg ipsilateral to the approach side, which lasted through the 3-month visit but was resolved by the 6-month visit. One patient (2.8\%) was found to have hypertrophy of the quadriceps contralateral to the approach side at the 12-month visit, which was resolved by the 2-year visit. Four patients (11\%) had postoperative facet joint pain, all in hybrid cases. All patients were 2 years or more postsurgery as of this writing, although 3 were lost to follow-up between the 1- and 2-year visits. In 2 cases (5.6\%), removal of the TDR device and revision to fusion were required due to unresolved pain. At 2 years' follow-up, the average visual analog scale and Oswestry Disability Index scores had improved 69.6\% and 61.4\%, respectively, and ROM averaged 8.6°, well within physiological norms. CONCLUSIONS: long-term results of a laterally placed TDR device demonstrate maintenance of pain relief and functional improvement. The benefits of this technique-minimal morbidity, avoiding mobilization of the great vessels, preserving the ALL, biomechanically stable orientation, and broader revision options-suggest a promising new direction for TDR procedures. This article was published in J Neurosurg Spine and referenced in Journal of Spine

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