alexa Lymphatic mapping and sentinel lymph node detection in women with cervical cancer.
Oncology

Oncology

Cancer Surgery

Author(s): Frumovitz M, Ramirez PT, Levenback CF, Frumovitz M, Ramirez PT, Levenback CF

Abstract Share this page

Abstract Lymphatic mapping and sentinel node detection have been applied to almost every solid tumor and sentinel node status have become part of the American Joint Commission on Cancer (AJCC) staging criteria in both breast cancer and malignant melanoma. As the presence of metastatic disease in lymph nodes is the most important prognostic factor on survival in women with cervical cancer, the ability to reliably detect sentinel nodes might triage women to adjuvant radiotherapy without the need for full lymphadenectomies and their associated morbidity. To date, multiple international investigators have performed single institution investigations with promising results. Overall, 831 women have been undergoing lymphatic mapping and sentinel node detection as part of their cervical cancer therapy as reported in the literature. Combining results from all these studies, a sentinel node was identified in 90\% of cases with an overall sensitivity of detecting metastatic disease of 92\% with an 8\% false negative rate. The overall negative predictive value was over 97\%. There remain controversies in moving forward with accepting sentinel node biopsy as the standard in treating women cervical cancer including 1) determining an acceptable false-negative rate, 2) establishing the importance of micrometastatic disease or isolated tumor cells in sentinel nodes, and 3) discovering the minimum number of cases a surgeon needs to become proficient in mapping techniques. Large, multi-institutional studies in both Europe and the United States are nearing completion and their results should help guide the future direction for sentinel node technologies in the treatment of cervical cancer. This article was published in Gynecol Oncol and referenced in Cancer Surgery

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords