Author(s): Harvey NL, Srinivasan RS, Dillard ME, Johnson NC, Witte MH,
Abstract Share this page
Abstract Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.
This article was published in Nat Genet
and referenced in Journal of Clinical & Cellular Immunology