alexa Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity.
Immunology

Immunology

Journal of Clinical & Cellular Immunology

Author(s): Harvey NL, Srinivasan RS, Dillard ME, Johnson NC, Witte MH,

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Abstract Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease. This article was published in Nat Genet and referenced in Journal of Clinical & Cellular Immunology

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