alexa Lymphocyte traffic and positioning in vivo: an expanded role for the ECM, the VLA proteins and the cytokines.


Journal of Clinical & Cellular Immunology

Author(s): de Sousa M

Abstract Share this page

Abstract The continuous circulation of lymphocytes between blood and lymph, constitutes, with the specific recognition of foreign antigens and with memory, one of the hallmarks of the immunological system. In the routine process of recirculating between blood and lymph in adult life, lymphocytes display the unique capacity of recognizing "self within self". The physiological recognition of "self within self" is expressed at three levels: (1) an overall ability to distinguish between peripheral lymphoid and non-lymphoid organs, (2) the ability of lymphocyte subpopulations to discriminate between peripheral lymphoid organs, (3) a fine recognition of distinct microenvironments within the peripheral lymphoid organs. Historically, interest in regulation of entry into the lymph dominated this field, focusing primarily on the interaction of lymphocytes with post-capillary venules with high endothelium found in some higher vertebrate lymph nodes. Lymphocytes, however, enter the lymph in species without lymph nodes, and lymphocytes recirculation is well established in fetal life. Regardless of route of entry, lymphocytes in birds, fish, rodents, and humans enter the peripheral lymphoid organs and display the capacity to segregate and arrange themselves in distinct territories, a phenomenon called "ecotaxis". This paper reviews the evidence for the relative contribution of so called specialized lymphocyte endothelium interactions and other interactions, to the physiological regulation of lymphocyte traffic and positioning. Of the latter, interactions of lymphocytes with the ECM appear of some significance for two reasons: there is a selective distribution of some ECM components in peripheral lymphoid organ areas, as recently shown for tenascin in the thymus-dependent zones (Chilosi et al., Am J Pathol 143: 1348-1355, 1993). This selective distribution may serve as a basis for preferential T cell migration through those zones. The abnormal expression of tenascin in non-lymphoid organs with autoimmune lesions may serve as an identical basis for abnormal T lymphocyte migration in autoimmunity (Chilosi, personal communication). Additional evidence for abnormal cell-ECM interactions playing a role in autoimmune-like lesions comes from the recent observations in TGF-beta 1 knockout mice, in which mononuclear cell infiltration of the heart and lungs has been corrected by the systemic administration of synthetic FN peptides (Hines at al., PNAS 91:5187-5191, 1994). Changes in expression of ECM components have aso being described in rat heart allografts preceding lymphocyte accumulation in the process of allograft rejection (Coito et atl. Transplantation 57:599-605, 1994).(ABSTRACT TRUNCATED AT 400 WORDS)
This article was published in Pathol Res Pract and referenced in Journal of Clinical & Cellular Immunology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version