Author(s): Olesen M, Eriksson S, Bohr J, Jrnerot G, Tysk C
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Abstract BACKGROUND: Lymphocytic colitis is characterised by chronic diarrhoea and specific microscopic changes in a macroscopically normal colonic mucosa. We report clinical features and treatment outcome in a large patient cohort. METHODS: Patients were searched for in 24 Swedish gastroenterology clinics. The biopsy material was reassessed using strict histopathological criteria. Clinical data were obtained from medical notes. RESULTS: Lymphocytic colitis was diagnosed in 199 cases. The female:male ratio was 2.4:1. Median age at diagnosis was 59 (48-70) years. The most frequent symptoms were diarrhoea (96\%), abdominal pain (47\%), and weight loss (41\%). The course was chronic intermittent in 30\% of patients, chronic continuous in 7\%, and a single attack in 63\%, and in these cases the disease duration was 6 (4-11) months. Seventy nine (40\%) patients reported associated diseases, of which thyroid disorders, coeliac disease, and diabetes mellitus were the most common. In 34 first or second degree relatives of 24 (12\%) patients, a family history of ulcerative colitis, Crohn's disease, collagenous colitis, or coeliac disease was reported. Drug induced disease was suspected in 19 (10\%) patients. A non-significant peak of disease onset was seen in December-January. More than 80\% of treated patients improved on corticosteroids, including budesonide. CONCLUSIONS: A family history of other bowel disorders is a new finding. The sudden onset and single attack of limited duration may support a possible infectious cause in some cases. Drugs may cause lymphocytic colitis.
This article was published in Gut
and referenced in International Journal of Inflammation, Cancer and Integrative Therapy