alexa Macrophage activation by the polysaccharide arabinogalactan isolated from plant cell cultures of Echinacea purpurea
Oncology

Oncology

Journal of Carcinogenesis & Mutagenesis

Author(s): Luettig B, Steinmller C, Gifford GE, Wagner H, LohmannMatthes ML

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In this study, acidic arabinogalactan, a highly purified polysaccharide from plant cell cultures of Echinacea purpurea, with a molecular weight of 75,000, was effective in activating macrophages to cytotoxicity against tumor cells and micro-organisms (Leishmania enriettii). Furthermore, this polysaccharide induced macrophages to produce tumor necrosis factor (TNF-alpha), interleukin-1 (IL-1), and interferon-beta 2. Arabinogalactan did not activate B cells and did not induce T cells to produce interleukin-2, interferon-beta 2, or interferon-gamma, but it did induce a slight increase in T-cell proliferation. When injected ip, this agent stimulated macrophages, a finding that may have therapeutic implications in the defense against tumors and infectious diseases.

This article was published in J Natl Cancer Inst. and referenced in Journal of Carcinogenesis & Mutagenesis

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