alexa Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control


Journal of Blood & Lymph

Author(s): Nagtegaal ID, van de Velde CJ

Abstract Share this page

Search term Clear input Advanced Help NCBI will be testing https on public web servers from 1:00-4:00 PM EDT (17:00-20:00 UTC) on Monday, October 24. You may experience problems with NCBI services, especially file downloads, during that time. Please plan accordingly. Read more. Result Filters Format: Abstract Send to J Clin Oncol. 2002 Apr 1;20(7):1729-34. Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control. Nagtegaal ID1, van de Velde CJ, van der Worp E, Kapiteijn E, Quirke P, van Krieken JH; Cooperative Clinical Investigators of the Dutch Colorectal Cancer Group. Author information Abstract PURPOSE: Quality assessment and assurance are important issues in modern health care. For the evaluation of surgical procedures, there are indirect parameters such as complication, recurrence, and survival rates. These parameters are of limited value for the individual surgeon, and there is an obvious need for direct parameters. We have evaluated criteria by which pathologists can judge the quality or completeness of the resection specimen in a randomized trial for rectal cancer. PATIENTS AND METHODS: The pathology reports of all patients entered onto a Dutch multicenter randomized trial were reviewed. All participating pathologists had been instructed by workshops and videos in order to obtain standardized pathology work-up. A three-tiered classification was applied to assess completeness of the total mesorectal excision (TME). Prognostic value of this classification was tested using log-rank analysis of Kaplan-Meier survival curves using the data of all patients who did not receive any adjuvant treatment. RESULTS: Included were 180 patients. In 24% (n = 43), the mesorectum was incomplete. Patients in this group had an increased risk for local and distant recurrence, 36.1% v. 20.3% recurrence in the group with a complete mesorectum (P =.02). Follow-up is too short to observe an effect on survival rates. CONCLUSION: A patient's prognosis is predicted by applying a classification of macroscopic completeness on a rectal resection specimen. We conclude that pathologists are able to judge the quality of TME for rectal cancer. With this direct interdisciplinary assessment instrument, we establish a new role of the pathologist in quality control.

  • To read the full article Visit
  • Open Access
This article was published in J Clin Oncol. 2002 and referenced in Journal of Blood & Lymph

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 7th World Hematologists Congress May 08-09, 2017 Barcelona, Spain
    May 08-09, 2017 Barcelona, Spain
  • 8th International Conference on Blood Cancer & Treatment June 26-27, 2017 London, UK
    June 26-27, 2017 London, UK
  • International Conference on Hematology and Oncology June 29-July 01, 2017 Bangkok, Thailand
    June 29-July 01, 2017 Bangkok, Thailand
  • 9th International Conference on Hematology November 02-03, 2017 Las Vegas, USA
    November 02-03, 2017 Las Vegas, USA
  • 11th International Conference on Leukemia and Hematologic Oncology December 04-05, 2017 Madrid, Spain
    December 04-05, 2017 Madrid, Spain

Relevant Topics

OMICS International Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version