Author(s): Erickson KL, Beutler JA, Gray GN, Cardellina JH nd, Boyd MR
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Abstract Seven new sesquiterpenes, majapolenes A  and B , majapolone , and majapols A , B , C , and D , were isolated from a Philippine collection of Laurencia majuscula. With the exception of majapolene B , all compounds were isolated as inseparable diastereomeric mixtures. Structure elucidation was achieved by spectroscopic methods. Majapolene A , a dioxabicyclo[2.2.2]-alkene, displayed modest activity in the NCI 60-cell line cytotoxicity screen. Majapolene A was also found as a major component of a Philippine collection of Laurencia caraibica.
This article was published in J Nat Prod
and referenced in Journal of Molecular and Genetic Medicine