alexa Majapolene A, a cytotoxic peroxide, and related sesquiterpenes from the red alga Laurencia majuscula.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular and Genetic Medicine

Author(s): Erickson KL, Beutler JA, Gray GN, Cardellina JH nd, Boyd MR

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Abstract Seven new sesquiterpenes, majapolenes A [1] and B [2], majapolone [3], and majapols A [4], B [5], C [6], and D [7], were isolated from a Philippine collection of Laurencia majuscula. With the exception of majapolene B [2], all compounds were isolated as inseparable diastereomeric mixtures. Structure elucidation was achieved by spectroscopic methods. Majapolene A [1], a dioxabicyclo[2.2.2]-alkene, displayed modest activity in the NCI 60-cell line cytotoxicity screen. Majapolene A was also found as a major component of a Philippine collection of Laurencia caraibica.
This article was published in J Nat Prod and referenced in Journal of Molecular and Genetic Medicine

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