Author(s): Hesdorffer DC, Hauser WA, Annegers JF, Cascino G
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Abstract We tested the hypothesis that major depression meeting DSM-III-R criteria or medical therapies for depression increase the risk for unprovoked seizures. Major depression was associated with a sixfold increased risk for unprovoked seizures (95\% CI, 1.56-22). The risk remained increased even when controlling for age, sex, length of medical follow-up, and medical therapies for depression. In the absence of known prior neurological insult, major depression is associated with an increased risk for unprovoked seizures.
This article was published in Ann Neurol
and referenced in Brain Disorders & Therapy